HEPATOPROTECTIVE EFFECT AND GC-MS ANALYSIS OF TRADITIONALLY USED BOSWELLIA SACRA OLEO GUM RESIN (FRANKINCENSE) EXTRACT IN RATS

Authors

  • Mohammed Asad College of Applied Medical Sciences, Shaqra University, Saudi Arabia
  • Meshal Alhumoud

DOI:

https://doi.org/10.21010/ajtcam.v12i2.1

Keywords:

Boswellia sacra, hepatoprotective, carbon tetrachloride, frankincense, liver damage.

Abstract

Background: The water extract of oleo-gum-resin of Boswellia sacra Fleuckiger (Burseraceae) is used in the treatment of liver problems in the Middle East and Arab-African countries. The present study was carried out to evaluate its effect on liver injury induced by carbon tetrachloride in acute and chronic liver injury models. Materials and Methods: The Boswellia sacra extract was administered at doses of 2 ml/kg and 5 ml/kg. Silymarin, a known hepato-protective agent was used as standard. The extract was subjected to GC-MS analysis to determine the presence of various phyto-constituents. Results: The Boswellia sacra extract at tested doses of 2 ml/kg and 5 ml/kg significantly reduced the elevated serum levels of biomarkers in liver damage. The hepatoprotective effect was supported by changes in histopathology. The GC-MS analysis of the extract revealed the presence of several phyto-constituents that included menthol, 3-cyclohexen-1-ol and octanoic acid. Conclusion: The water extract oleo-gum-resin of Boswellia sacra possesses hepatoprotective activity, as claimed by traditional healers within the Middle East and Arab-African countries.

Author Biography

Mohammed Asad, College of Applied Medical Sciences, Shaqra University, Saudi Arabia

Associate Professor of Pharmacology

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Published

2015-03-06

How to Cite

Asad, M., & Alhumoud, M. (2015). HEPATOPROTECTIVE EFFECT AND GC-MS ANALYSIS OF TRADITIONALLY USED BOSWELLIA SACRA OLEO GUM RESIN (FRANKINCENSE) EXTRACT IN RATS. African Journal of Traditional, Complementary and Alternative Medicines, 12(2), 1–5. https://doi.org/10.21010/ajtcam.v12i2.1

Issue

Vol. 12 No. 2 (2015)

Section

Research Papers

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