ETHANOL EXTRACT OF CARTHAMUS TINCTORIUS L. SHOWS ANTI-THROMBOSIS ACTIVITY IN RATS

Authors

  • Tong-bin Ding
  • Li-guo Jian
  • Jiang-tao Zhao
  • Shi-chao Liu
  • Jin-ying Zhang
  • Sheng Hao Wu

DOI:

https://doi.org/10.21010/ajtcam.v12i3.15

Keywords:

Carthamus tinctorius L., thrombosis, TXB2, 6-keto-PGF1α

Abstract

Background: The study was designed to study the anti-thrombosis activity of Carthamustinctorius L. (CTL) ethanol extraction rats. Material and Methods: Common carotid artery FeCl3-induced thrombus and inferior vena cava thrombosis occlusion time, plasma concentrations of thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α) were measured in rats. Results: Venous occlusion time was prolonged in rats. Arterial and venous thrombus weights were dose-dependently reduced in CTL groups.TXB2 decreased and 6-keto-PGF1α increased with CTL and aspirin, with an association between 6-keto-PGF1α/TXB2 and arterial or venous thrombus weight for all products, and for occlusion time with CTL but not for aspirin. Conclusion: The experimental effects of CTL on thrombosis in rats were confirmed. Again, further explorations of putative clinical effects appear justified.

Author Biography

Sheng Hao Wu

The First Affiliated Hospital of ZhengzhouUniversity, Zhengzhou, Henan, 450000, China.

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Published

2015-04-05

How to Cite

Ding, T.- bin, Jian, L.- guo, Zhao, J.- tao, Liu, S.- chao, Zhang, J.- ying, & Wu, S. H. (2015). ETHANOL EXTRACT OF CARTHAMUS TINCTORIUS L. SHOWS ANTI-THROMBOSIS ACTIVITY IN RATS. African Journal of Traditional, Complementary and Alternative Medicines, 12(3), 120–124. https://doi.org/10.21010/ajtcam.v12i3.15

Issue

Vol. 12 No. 3 (2015)

Section

Research Papers

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