THE PREVENTIVE EFFECT AND ENHANCE IMMUNITY FUNCTION OF BU-ZHONG-YI-QIWAN ON S180 TUMOR MICE.

Authors

  • Fang Hu
  • Xiaoya Liu
  • Xinyue Chen
  • Can Li
  • Ruijuan Zhu
  • Huan Han
  • Yingdong LI
  • Shilan Feng School of Pharmacy, Lanzhou University,

DOI:

https://doi.org/10.21010/ajtcam.v13i3.8

Keywords:

Bu-zhong-yi-qi wan, S180 tumor-bearing mice, preventive effect, enhance immunity function

Abstract

Background: To evaluate the preventive effect and enhance immunity functions of Bu-zhong-yi-qi wan in vivo. Materials and Methods: S180 tumor mice model was established by subcutaneous injection a dose of 0.2 ml (1×107/ml) at the right oxter. The inhibitory rates, spleen indexes and thymus indexes were calculated. Splenic lymphocyte proliferative activity assay and phagocytosis activity of peritoneal macrophages were done. Interferon (IFN-γ), interleukin (IL-2) and tumor necrotic factor (TNF-α) in serum were detected. Results: In the S180 tumor-bearing mice, Bu-zhong-yi-qi wan with medium-dose (975 mg/kg, 100 mg/l) had potent preventive effect and anti-tumor effect, macrophage phagocytosis and Con A-stimulated splenocyte proliferation were increased as compared with model control treatment. Bu-zhong-yi-qi wan could take part in the immune response by promoting the proliferation and differentiation of Tcells, increasing the activity of the macrophages, inducing the generation of cell factor IL-2, TNF-α, IFN-γ. Conclusion: It proved that Bu-zhong-yi-qi wan of medium-dose had great preventive effect and could enhance immunity function.

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Published

2016-03-15

How to Cite

Hu, F., Liu, X., Chen, X., Li, C., Zhu, R., Han, H., LI, Y., & Feng, S. (2016). THE PREVENTIVE EFFECT AND ENHANCE IMMUNITY FUNCTION OF BU-ZHONG-YI-QIWAN ON S180 TUMOR MICE. African Journal of Traditional, Complementary and Alternative Medicines, 13(3), 60–65. https://doi.org/10.21010/ajtcam.v13i3.8

Issue

Vol. 13 No. 3 (2016)

Section

Research Papers

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