THE ANTIULCER EFFECTS OF THE METHANOL EXTRACT OF THE LEAVES OF ASPILIA AFRICANA (ASTERACEAE) IN RATS

Authors

  • Télesphore Benoît Nguelefack
  • Pierre Watcho
  • Sylvie Lea Wansi
  • Ngetla Manyineh Mbonuh
  • Dieudonne Ngamga
  • Pierre Tane
  • Albert Kamanyi

Keywords:

Aspilia africana, antiulcer, rat

Abstract

Aspilia africana (Asteraceae) is a plant currently used in Cameroon ethnomedicine for the treatment of stomach ailments. The methanol extract of the leaves of A. africana was investigated against gastric ulcerations induced by HCl/ethanol and pylorus-ligation. With both methods, the extract inhibited gastric ulcerations in a dose-related manner. Oral administration of the plant extract at the doses of 0.5 and 1 g/kg reduced gastric lesions induced by HCl/ethanol by 79 % and 97 % respectively. The extract at the dose of 1 g/kg reduced gastric lesion in the pylorus ligated rats by 52 % although the gastric acidity remained higher as compared to the control. These findings show that methanol extract of the leaves of A. africana possess potent antiulcer properties.

Author Biographies

Télesphore Benoît Nguelefack

Department of Animal biology, Faculty of Science, University of Dschang, BP 67 Dschang, Cameroon

Pierre Watcho

Department of Animal biology, Faculty of Science, University of Dschang, BP 67 Dschang, Cameroon

Sylvie Lea Wansi

Department of Animal biology, Faculty of Science, University of Dschang, BP 67 Dschang, Cameroon

Ngetla Manyineh Mbonuh

Department of Animal biology, Faculty of Science, University of Dschang, BP 67 Dschang, Cameroon

Dieudonne Ngamga

Department of Chemistry, Faculty of Science, University of Dschang, BP 67 Dschang, Cameroon

Pierre Tane

Department of Chemistry, Faculty of Science, University of Dschang, BP 67 Dschang, Cameroon

Albert Kamanyi

Department of Chemistry, Faculty of Science, University of Dschang, BP 67 Dschang, Cameroon

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Published

2006-01-07

How to Cite

Nguelefack, T. B., Watcho, P., Wansi, S. L., Mbonuh, N. M., Ngamga, D., Tane, P., & Kamanyi, A. (2006). THE ANTIULCER EFFECTS OF THE METHANOL EXTRACT OF THE LEAVES OF ASPILIA AFRICANA (ASTERACEAE) IN RATS. African Journal of Traditional, Complementary and Alternative Medicines, 2(3), 233 –. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/26

Issue

Vol. 2 No. 3 (2005)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

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