ANTIGENOTOXIC EFFECT OF FERULIC ACID IN 7,12-DIMETHYL BENZ(A)-ANTHRACENE (DMBA) INDUCED GENOTOXICITY
Keywords:
DMBA, ferulic acid, genotoxicity, chromosomal aberrations,Abstract
The antigenotoxic effect of ferulic acid was carried out by evaluating the cytogenetic markers, the micronuclei frequency and chromosomal aberrations, in the bone marrow of hamsters in 7,12-dimethylbenz(a)anthracene (DMBA) induced genotoxicity. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30mg kg-1 b.w). Pretreatment of ferulic acid orally at a dose of 40mg kg-1 b.w for five days significantly reduced the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and the percentage of chromosomal aberrations in hamster’s bone marrow. Our results thus suggest that ferulic acid has potent antigenotoxic effect in DMBA induced genotoxicity in golden Syrian hamsters.Downloads
Published
2007-09-04
How to Cite
Balakrishnan, S., Menon, V. P., Manoharan, S., & Rajalingam, K. (2007). ANTIGENOTOXIC EFFECT OF FERULIC ACID IN 7,12-DIMETHYL BENZ(A)-ANTHRACENE (DMBA) INDUCED GENOTOXICITY. African Journal of Traditional, Complementary and Alternative Medicines, 5(1), 32–38. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/242
Issue
Section
Research Papers
License
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.
