ELECTROACUPUNCTURING AT ZUSANLI POINT (ST36) ATTENUATES PRO-INFLAMMATORY CYTOKINE RELEASE AND ORGAN DYSFUNCTION BY ACTIVATING CHOLINERGIC ANTI-INFLAMMATORY PATHWAY IN RAT WITH ENDOTOXIN CHALLENGE

Authors

  • Qi Song
  • Sen Hu
  • Haibin Wang
  • Yi Lv
  • Xian Shi
  • Ziyong Sheng
  • Wei Sheng

Keywords:

Electro-acupuncture Lipopolysaccharide Cytokine Cholinergic anti-inflammatory pathway

Abstract

To investigate the effect of electro-acupuncturing (EA), at Zusanli point (ST36) on plasma cytokine release and organ dysfunction and their mechanism in conscious rats with endotoxin challenge. EA at Zusanli points obviously lowered the elevated levels of plasma TNF-α, and attenuated changes in parameters relevant to various organ functions at 2 h after LPS challenge. ɑ-BGT injection or bilateral cervical vagotomy could weaken or eliminate the effects of EA, and further aggravated the elevated levels of pro-inflammatory cytokines and organ dysfunction. The results suggested that EA at Zusanli points significantly reduced the release of pro-inflammatory cytokines and organ dysfunction after LPS challenge by activating cholinergic anti-inflammatory pathway.

Author Biography

Qi Song

The Oncotherapy center of the People’s Liberation Army General Hospital, Beijing 100853 PRC

Downloads

Published

2014-01-23

How to Cite

Song, Q., Hu, S., Wang, H., Lv, Y., Shi, X., Sheng, Z., & Sheng, W. (2014). ELECTROACUPUNCTURING AT ZUSANLI POINT (ST36) ATTENUATES PRO-INFLAMMATORY CYTOKINE RELEASE AND ORGAN DYSFUNCTION BY ACTIVATING CHOLINERGIC ANTI-INFLAMMATORY PATHWAY IN RAT WITH ENDOTOXIN CHALLENGE. African Journal of Traditional, Complementary and Alternative Medicines, 11(2), 469–474. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/2353

Issue

Vol. 11 No. 2 (2014)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.