ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF HIPPOCRATEA INDICA ROOT BARK AND POGA OLEOSA FRUITS

Authors

  • O. O. Ogbole
  • M. N. Ekor
  • B. B. Oluremi
  • E. O. Ajaiyeoba
  • A. A. Gbolade
  • M. A. Ayoola
  • A. A. Adeyemi

Keywords:

Hippocratea indica, Poga oleosa, anti-inflammatory, antimicrobial

Abstract

The methanolic extracts of Hippocratea indica root bark and Poga oleosa fruits were investigated for anti-inflammatory and antimicrobial activities. Both extracts inhibited carrageenan-induced paw oedema significantly in rats in a dose-dependent manner in 4 h. H. indica inhibited oedema significantly at the minimal dose (125 mg/ml, p< 0.05) from 2 h onward, and gave 100% inhibition in 4 h. at 250 mg/kg. It was shown to be a more potent anti-inflammatory agent than P. oleosa. Also, H. indica extract exhibited greater antimicrobial activity against tested bacteria, with Staphylococcus aureus being the most susceptible bacterium (MIC, 16 mg/ml). Both plants were inactive against Candida albicans. These results confirm the anti-inflammatory and antibacterial activities of the two plants.

Author Biographies

O. O. Ogbole

Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu campus, Ogun State, Nigeria

M. N. Ekor

Department of Pharmacology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ikenne campus, Ogun State, Nigeria

B. B. Oluremi

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu campus, Ogun State, Nigeria

E. O. Ajaiyeoba

Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Oyo State, Nigeria

A. A. Gbolade

Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu campus, Ogun State, Nigeria

M. A. Ayoola

Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu campus, Ogun State, Nigeria

A. A. Adeyemi

Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu campus, Ogun State, Nigeria

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Published

2007-02-16

How to Cite

Ogbole, O. O., Ekor, M. N., Oluremi, B. B., Ajaiyeoba, E. O., Gbolade, A. A., Ayoola, M. A., & Adeyemi, A. A. (2007). ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF HIPPOCRATEA INDICA ROOT BARK AND POGA OLEOSA FRUITS. African Journal of Traditional, Complementary and Alternative Medicines, 4(3), 372–376. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/231

Issue

Vol. 4 No. 3 (2007)

Section

Research Papers

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