ANTIHYPERGLYCEMIC EFFECTS OF SEPARATE AND COMPOSITE EXTRACT OF ROOT OF MUSA PARADISIACA AND LEAF OF COCCINIA INDICA IN STREPTOZOTOCIN-INDUCED DIABETIC MALE ALBINO RAT

Authors

  • C. Mallick
  • K. Chatterjee
  • M. GuhaBiswas
  • D. Ghosh

Keywords:

Diabetes, Glycaemic index, Insulin, Musa paradisiaca, Coccinia indica

Abstract

We evaluated the antihyperglycaemic properties of aqueous-methanolic (40:60) extract of root of Musa paradisiaca and leaf of Coccinia indica in separate as well as in composite manner by conducting experiment on streptozotocin-induced diabetic rats. We measured food and water intake ability, the fasting blood glucose level, glucose tolerance, activities of important carbohydrate metabolic enzymes like glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, hexokinase in liver along with quantification of glycogen in liver and in skeletal muscle and serum insulin level. We noted that after treatment of aqueous methanolic extract of above plant parts in separate as well as in composite manner at a concentration of 80mg/100g body weight/day to streptozotocin-induced diabetic rat resulted in a significant remedial effect on blood glucose level as well as carbohydrate metabolic enzymes and the quantity of liver and skeletal muscle glycogen. Serum insulin level that was diminished in streptozotocin-induced diabetic rat recovered significantly after the co-administration of extract of above plant parts. All the above parameters showed a more potent remedial effect after composite extract treatment with respect to separate treatment and none of the extract has any general metabolic toxicity induction

Author Biographies

C. Mallick

Reproductive Endocrinology and Family Welfare Research Unit, Department of Human Physiology with Community Health

K. Chatterjee

Bio-Medical Laboratory Science and Management Vidyasagar University, Midnapore-721 102 West Bengal, India

M. GuhaBiswas

Bio-Medical Laboratory Science and Management Vidyasagar University, Midnapore-721 102 West Bengal, India

D. Ghosh

Bio-Medical Laboratory Science and Management Vidyasagar University, Midnapore-721 102 West Bengal, India

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Published

2007-02-16

How to Cite

Mallick, C., Chatterjee, K., GuhaBiswas, M., & Ghosh, D. (2007). ANTIHYPERGLYCEMIC EFFECTS OF SEPARATE AND COMPOSITE EXTRACT OF ROOT OF MUSA PARADISIACA AND LEAF OF COCCINIA INDICA IN STREPTOZOTOCIN-INDUCED DIABETIC MALE ALBINO RAT. African Journal of Traditional, Complementary and Alternative Medicines, 4(3), 362–371. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/230

Issue

Vol. 4 No. 3 (2007)

Section

Research Papers

License

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