COMPARATIVE ANTI-INFLAMMATORY AND HEPATOPROTECTIVE ACTIVITIES OF ASTRAGALUS GUMMIFER LABILL HERB AND ROOTS IN RATS

Authors

  • Hasan Soliamn Yusufoglu
  • Aftab Alam salman bin abdulaziz university, college of pharmacy, department of pharmacognosy alkharj-11942
  • Prawez Alam salman bin abdulaziz university, college of pharmacy, department of pharmacognosy alkharj-11942
  • Mohammad Ayman Salkini salman bin abdulaziz university, college of pharmacy, department of pharmacognosy alkharj-11942
  • Ahmed Mohammed Zaghloul salman bin abdulaziz university, college of pharmacy, department of pharmacognosy alkharj-11942

Keywords:

Astragalus gummifer, Anti-inflammatory, Hepatoprotective, CCl4, carrageenan, Biochemical

Abstract

Background: The Astragalus gummifer (F. Fabaceae), herb and roots were studied for anti-inflammatory and hepatoprotective activities. Materials and method: The alcoholic extracts of Astragalus gummifer (F. Fabaceae), herb (AGHE), and roots (AGRE), were used for anti-inflammatory and hepatoprotective activities in Wister rats. The effects of AGHE and AGRE were compared with the standard drugs Phenylbutazone and silymarin, for anti-inflammatory and hepatoprotective activities respectively. Result: Both extracts showed significant anti-inflammatory activity (P< 0.001). AGRE showed comparatively more significant hepatoprotective activity (P< 0.001), than AGHE (P< 0.05); at doses of 250 and 500 mg/kg body weight as manifested by lowering the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin. The hepatoprotective activity was, also, supported by total protein (TP), malondialdehyde (MDA), nonprotein sulfhydryls (NP-SH), and histo-pathological studies of liver tissue. Discussion: To the best of our knowledge, this is the first report of the anti-inflammatory and hepatoprotective activities of Astragalus gummifer. The results of present studies indicated that both AGHE and AGRE can be used in inflammatory conditions, while investigation supports the use of AGRE in cases that hepatoprotection are required in the hepatotoxic conditions. More supportive studies are required before clinical recommendation.

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Published

2014-03-29

How to Cite

Yusufoglu, H. S., Alam, A., Alam, P., Salkini, M. A., & Zaghloul, A. M. (2014). COMPARATIVE ANTI-INFLAMMATORY AND HEPATOPROTECTIVE ACTIVITIES OF ASTRAGALUS GUMMIFER LABILL HERB AND ROOTS IN RATS. African Journal of Traditional, Complementary and Alternative Medicines, 11(3), 268–274. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/2296

Issue

Vol. 11 No. 3 (2014)

Section

Research Papers

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