Vol 4 No 3 (2007)
Research Papers

APOPTOSIS INDUCING EFFECT OF ANDROGRAPHOLIDE ON TD-47 HUMAN BREAST CANCER CELL LINE

Sukardiman Harjotaruno
Bio
Aty Widyawaruyanti
Bio
- Sismindari
Bio
N. C. Zaini
Bio
Published February 16, 2007
Keywords
  • Andrographis paniculata Ness,
  • andrographolide,
  • TD-47 cell,
  • apoptosis
How to Cite
Harjotaruno, S., Widyawaruyanti, A., Sismindari, -, & Zaini, N. (2007). APOPTOSIS INDUCING EFFECT OF ANDROGRAPHOLIDE ON TD-47 HUMAN BREAST CANCER CELL LINE. African Journal of Traditional, Complementary and Alternative Medicines, 4(3), 345-351. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/227

Abstract

Andrographolide isolated from Andrographis paniculata Ness (Acanthaceae) at 0.35 mM , 0.70 mM and 1.40 mM induced DNA fragmentation and increased the percentage of apoptotic cells when TD-47 human breast cancer cell line was treated for 24 , 48 and 72 h. The results demonstrated that andrographolide can induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax , caspase-3 and decrease expression of bcl-2 determined by immunohistochemical analysis