STUDY ON THE ANTI-DEPRESSANT EFFECT OF CHAIHU GUIZHI DECOCTION AND ITS MECHINISIMS OF ACTIONS

Authors

  • Yu Liu
  • Chunmei Cao
  • Haijun Ding

Keywords:

Chaihu Guizhi Decoction, forced swimming, tail suspension test

Abstract

Background: Chaihu Guizhi has the effects of treating exogenous wind-cold; alternating episodes of chills and fever; noisy nose and retching; strong headache; chest and rib-side pain, and fullness, in clinical practice, it can also be used for the treatment of depression. The objective of this paper was to study the anti-depressant effect of Chaihu Guizhi decoction and its mechanism. Materials and Methods: The anti-depressant effect of Chaihu Guizhi decoction was investigated by forced swimming test, tail suspension test and antagonism of reserpine hypothermia test in mice. Results: Chaihu Guizhi decoction could significantly shorten immobility time of mice in the forced swimming test, and dose-dependence significantly shorten immobility time of mice in the tail suspension test, after administration of 50, 100, and 200mg/kg, Chaihu Guizhi decoction, a significant dose-dependent antagonism of reserpine-induced hypothermia was observed in mice of each treatment group. Conclusion: Chaihu Guizhi decoction has an antidepressant effect.

Author Biography

Chunmei Cao

Department of Physical Education, Tsinghua University, Beijing 100084, China.

Downloads

Published

2014-01-21

How to Cite

Liu, Y., Cao, C., & Ding, H. (2014). STUDY ON THE ANTI-DEPRESSANT EFFECT OF CHAIHU GUIZHI DECOCTION AND ITS MECHINISIMS OF ACTIONS. African Journal of Traditional, Complementary and Alternative Medicines, 11(2), 273–276. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/2266

Issue

Vol. 11 No. 2 (2014)

Section

Short communications

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.