EXPERIMENTAL STUDY ON THE INHIBITORY EFFECT OF SODIUM CANTHARIDINATE ON HUMAN HEPATOMA HEPG2 CELLS

Authors

  • Shi-Qi Wen
  • Quan Chen
  • Ming Hu

Keywords:

sodium cantharidinate, human hepatoma HepG2, MTT assay

Abstract

Backgroud: Cantharidin, and its derivatives can not only inhibit the proliferation of tumor cells, but can also induce tumor cell apoptosis. It shows cantharidin exhibits a wide range of reactivity in anticancer. The objective of this paper was to study the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells. Materials and Methods: MTT assay was used to detect the proliferation of HepG2 cells, and immunohisto-chemical method was used to detect the change in VEGF, protein level, and to determine the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells. Results: As results, sodium cantharidinate significantly inhibited the growth of HepG2 cells in a time-and dose-dependent manner. Conclusion: We conclude that sodium cantharidinate has an inhibitory effect on human hepatoma HepG2 cells.

Author Biography

Shi-Qi Wen

Department of Vascular, Gansu Provincial Hospital, Lanzhou 730000, China

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Published

2013-10-28

How to Cite

Wen, S.-Q., Chen, Q., & Hu, M. (2013). EXPERIMENTAL STUDY ON THE INHIBITORY EFFECT OF SODIUM CANTHARIDINATE ON HUMAN HEPATOMA HEPG2 CELLS. African Journal of Traditional, Complementary and Alternative Medicines, 11(1), 131–134. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/2207

Issue

Vol. 11 No. 1 (2014)

Section

Short communications

License

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