STUDY ON THE ANTI-CEREBRAL ISCHEMIA EFFECT OF BORNEOL AND ITS MECHANISM

Authors

  • Qing-xia Kong
  • Zhao-ying Wu
  • Xu Chu
  • Ru-qing Liang
  • Min Xia
  • Lei Li

Keywords:

borneol, cerebral ischemia-reperfusion, IL-1β, TNF-α, ICAM-1

Abstract

Background: Borneol is the processed item from resin of Dryobalanops aromatica Gaertn. f. It can enhance the activity of antioxidant enzymes in brain tissue and reduce inflammatory response by improving the energy metabolism of ischemic brain regions, and thereby reduces brain tissue damage. The objective of this paper was to study the anti-cerebral ischemia effect of borneol and its mechanism. Materials and Methods: The anti-cerebral ischemia effect of borneol was studied by ligation of bilateral common carotid arteries (CCA), and vagus nerves in mice and the acute cerebral ischemia-reperfusion experiment in rats. Results: Compared with the blank and solvent control groups, the borneol low-; medium-; and high-dose groups can significantly prolong the gasping time of mice after decapitation, and extend the survival time of mice after ligation of bilateral CCA, and vagus nerves. Conclusion: Compared with the Xueshuantong injection group, the prolongation of survival time of mice after ligation of bilateral CCA, and vagus nerves was more apparent in the high-dose borneol experimental group; each experimental group can significantly reduce the number of leukocyte infiltration, the number of ICAM-1-positive vessels, as well as the number of TNF-α-positive cells. Conclusion: Borneol has an anti-cerebral ischemia effect.

Author Biography

Qing-xia Kong

Department of Neurology, Affiliated Hospital of Shan’dong Ji’ning Medical College,China; 272129

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Published

2013-10-28

How to Cite

Kong, Q.- xia, Wu, Z.- ying, Chu, X., Liang, R.- qing, Xia, M., & Li, L. (2013). STUDY ON THE ANTI-CEREBRAL ISCHEMIA EFFECT OF BORNEOL AND ITS MECHANISM. African Journal of Traditional, Complementary and Alternative Medicines, 11(1), 161–164. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/2199

Issue

Vol. 11 No. 1 (2014)

Section

Short communications

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