SPASMOGENIC EFFECT OF THE AQUEOUS EXTRACT OF TAMARINDUS INDICA L. (CAESALPINIACEAE) ON THE CONTRACTILE ACTIVITY OF GUINEA-PIG TAENIA COLI.

Authors

  • A. Souza
  • K. J. Aka

Keywords:

Contractions, Smooth muscle, Taenia coli, Tamarindus indica

Abstract

The effect of aqueous extract of Tamarindus indica (AETI) was studied on the guinea pig taenia coli, due to its use for treatment of constipation in traditional medicines. AETI, at concentrations ranging from 10-8 mg/ml to 10-2 mg/ml, increased the spontaneous contractile activity of guinea pig taenia coli in a dose-dependent manner (EC50= 4x10-6 mg/ml). This activity was unaffected by atropine. In high K+, Ca2+-free solution containing EDTA, AETI as well as acetylcholine, used as a control, induced tonic contraction. These results suggest that the plant extract exert a spasmogenic effect that would not involve cholinergic mechanism of action. However, these active principles could mobilize both extra cellular calcium and intracellular calcium from internal stores.

Author Biographies

A. Souza

Laboratoire de Physiologie Animale, Electrophysiologie et de Pharmacologie, Faculté des Sciences, Université des Sciences et Techniques de Masuku, Franceville Gabon

K. J. Aka

Laboratoire de Physiologie Animale, UFR Biosciences, Université de Cocody, Abidjan Côte d’Ivoire.

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Published

2007-02-16

How to Cite

Souza, A., & Aka, K. J. (2007). SPASMOGENIC EFFECT OF THE AQUEOUS EXTRACT OF TAMARINDUS INDICA L. (CAESALPINIACEAE) ON THE CONTRACTILE ACTIVITY OF GUINEA-PIG TAENIA COLI. African Journal of Traditional, Complementary and Alternative Medicines, 4(3), 261–266. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/218

Issue

Vol. 4 No. 3 (2007)

Section

Research Papers

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