STUDY ON ANTI-EHRLICH ASCITES TUMOUR EFFECT OF PINELLIA TERNATA POLYSACCHARIDE IN VIVO

Authors

  • Xiaogang Li
  • Ping Lu
  • Wanfu Zhang
  • Bo Li
  • Rong Yang
  • Kaiyuan Luo

Keywords:

Pinellia ternata polysaccharide, ascites tumour, SOD, MDA, GSH-Px

Abstract

The objectives of the study were to investigate the anti-tumour activity of Pinellia ternata polysaccharide in vivo, and to preliminarily explore the possible mechanism of its antitumour action. Mouse model of Ehrlich ascites tumour (solid tumour) was used to detect the serum SOD, MDA and GSH-Px levels in mouse and to measure the tumour inhibition rate and survival prolongation rate. The results showed that Pinellia ternata polysaccharide had some tumour inhibitory effect. Tumour weight of Pinellia ternata polysaccharide high-dose group was highly significantly different (P<0.01) compared with the model group. Tumour weight between Pinellia ternata polysaccharide medium-dose group and model group also had a significant difference (P<0.05). Moreover, in the Pinellia ternata polysaccharide high-dose group, survival prolongation rate of ascites tumour mice reached 62.23%, and mouse serum SOD, MDA and GSH-Px levels also rose in varying degrees. The study concluded that Pinellia ternata polysaccharide extract had some in vivo anti-tumour effects, which were probably associated with the enhancement of the body’s ability to scavenge excess free radicals by improving the body’s enzyme activity.

Author Biography

Xiaogang Li

Department of General Surgery, The Forth Affiliated Hospital of Kunming Medical University, Kunming 650021, China

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Published

2013-07-04

How to Cite

Li, X., Lu, P., Zhang, W., Li, B., Yang, R., & Luo, K. (2013). STUDY ON ANTI-EHRLICH ASCITES TUMOUR EFFECT OF PINELLIA TERNATA POLYSACCHARIDE IN VIVO. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 380–385. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1964

Issue

Vol. 10 No. 5 (2013)

Section

Research Papers

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