A STUDY ON INHIBITORY EFFECT OF SPICA PRUNELLAE EXTRACT ON T LYMPHOMA CELL EL-4 TUMOUR

Authors

  • Xingjiang Mao
  • Gengfu Wang
  • Wei Zhang
  • Shaoping Li

Keywords:

Spica prunellae, EL-4 solid tumour, tumour inhibition, mechanism

Abstract

The objective of the study was to investigate the in-vivo anti-tumour activity of Spica prunellae extract, and to preliminarily explore the possible mechanism of in-vivo anti-tumour effect of Spica prunellae extract. Tumour inhibition rate and tumour apoptosis-related protein status were determined using the mice model of transplanted T lymphoma cell EL-4 tumour, and by immunohistochemical method. The results revealed that Spica prunellae extract showed certain tumour inhibitory effect, and compared with the model group. Tumour weight in Spica prunellae high-dose group was highly significantly different (P<0.01). Tumour weight in Spica prunellae medium-dose group was also significantly different (P<0.05) compared with the model group. Spica prunellae high-dose group enabled the high expression of Bcl-2 protein (47.54%) and low expression of Bax protein (13.14%). The study concluded that Spica prunellae extract has certain in vivo anti-tumour effect, which may be achieved through regulation of apoptosis related proteins.

Author Biography

Xingjiang Mao

Department of General Surgery,the First Affiliated Hospital of Xinxiang Medical University, Wei Hui 453100, China

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Published

2013-07-04

How to Cite

Mao, X., Wang, G., Zhang, W., & Li, S. (2013). A STUDY ON INHIBITORY EFFECT OF SPICA PRUNELLAE EXTRACT ON T LYMPHOMA CELL EL-4 TUMOUR. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 318–324. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1949

Issue

Vol. 10 No. 5 (2013)

Section

Research Papers

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