A STUDY ON THE PROTECTIVE EFFECT OF SILYBUM MARIANUM EXTRACT ON HEPATIC ISCHEMIA-REPERFUSION INJURY

Authors

  • Shaojun Liu
  • Zhiheng Chen
  • Dongbo Cao
  • Fen Liu
  • Xiaoyan Wang
  • Lian Zhao
  • Rui Liu
  • Zhiming Xiao

Keywords:

Silybum marianum, hepatic ischemia-reperfusion injury, protective effect

Abstract

The objective of the study was to study the protective effect of Silybum marianum extract on hepatic ischemia-reperfusion injury. Rats were randomly divided into five groups; namely Silybum marianum extract high-, medium-, and low-dose protection groups, model group and control group. Hepatic ischemia-reperfusion injury model was prepared. Serum or plasma AST, ALT, MDA, TNF-α, IL-1β, IL-6 levels were measured. The results revealed that after liver injury, AST, ALT, MDA, TNF-α, IL-1β, and IL-6 levels significantly increased in succession, showing significant differences. We concluded that inflammatory cytokines participate in liver injury and that Silybum marianum extract can reduce the production of inflammatory cytokines, and thus can have a protective effect on hepatic ischemia and reperfusion.

Author Biography

Shaojun Liu

Department of Digestion Medicine, The Third Affiliated Hospital of Xiang Ya School of Medicine, Central South University, Changsha 410078, Hunan, People’s Republic of China

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Published

2013-07-04

How to Cite

Liu, S., Chen, Z., Cao, D., Liu, F., Wang, X., Zhao, L., Liu, R., & Xiao, Z. (2013). A STUDY ON THE PROTECTIVE EFFECT OF SILYBUM MARIANUM EXTRACT ON HEPATIC ISCHEMIA-REPERFUSION INJURY. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 310–312. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1947

Issue

Vol. 10 No. 5 (2013)

Section

Research Papers

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