PREVENTION OF RADIATION INDUCED HEMATOLOGICAL ALTERATIONS BY MEDICINAL PLANT ROSMARINUS OFFICINALIS, IN MICE

Authors

  • Garima Sancheti
  • P. K. Goyal

Keywords:

Gamma radiation, Glutathione, Hematology, Lipid peroxidation, Rosmarinus officinalis, Swiss albino mice

Abstract

The modulatory influence of Rosmarinus officinalis (rosemary) leaves extract was investigated in Swiss albino mice at a dose of 3 Gy gamma radiation. For this purpose, adult Swiss albino mice were irradiated with 3 Gy gamma rays in the presence (experimental) or absence (control) of rosemary (1000 mg/kg body wt.). These animals were necropsied and their blood was collected at days 1, 3, 5, 10, 20 and 30 post-irradiation. A decrease in the number of erythrocyte and leucocyte counts, hemoglobin content and hematocrit percentage was scored in the control group; whereas a recovery pattern was recorded in experimental animals and a normal value of hematological parameters were regained by day 30 post-treatment. In irradiated group, glutathione level was registered low in the blood, whereas a significant elevation was estimated in rosemary pre-treated animals. An increase in lipid peroxidation level above normal was evident in serum of irradiated mice, while a significant decrease in such values was noted in rosemary pretreated group. The present study suggests the possible radioprotective ability of rosemary extract.

Author Biographies

Garima Sancheti

Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur – 302 004 (India)

P. K. Goyal

Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur – 302 004 (India)

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Published

2006-11-13

How to Cite

Sancheti, G., & Goyal, P. K. (2006). PREVENTION OF RADIATION INDUCED HEMATOLOGICAL ALTERATIONS BY MEDICINAL PLANT ROSMARINUS OFFICINALIS, IN MICE. African Journal of Traditional, Complementary and Alternative Medicines, 4(2), 165–172. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/192

Issue

Section

Research Papers