THE ANTIPLASMODIAL AGENTS OF THE STEM BARK OF ENTANDROPHRAGMA ANGOLENSE (MELIACEAE)

Authors

  • Jean Bickii
  • Guy Raymond Feuya Tchouya
  • Jean Claude Tchouankeu
  • Etienne Tsamo

Keywords:

Plasmodium falciparum, Meliaceae, Entandrophragma angolense, Limonoids, Fatty acids, Triterpenoids, 7-obacunyl acetate, 24-methylenecycloartenol, anti-plasmodial activity.

Abstract

In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane – methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC50s of 2 and 5.4 µg/ml respectively. Other compounds were moderately active.

Author Biographies

Jean Bickii

Institut de Recherches Médicales et d’Etudes des Plantes Médicinales (I.M.P.M.), Laboratoire de Recherche sur le Paludisme, Yaoundé, Cameroon

Guy Raymond Feuya Tchouya

Faculty of Science, University of Yaoundé 1, P. O. Box 812 Yaoundé, Cameroon

Jean Claude Tchouankeu

Faculty of Science, University of Yaoundé 1, P. O. Box 812 Yaoundé, Cameroon

Etienne Tsamo

Faculty of Science, University of Yaoundé 1, P. O. Box 812 Yaoundé, Cameroon

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Published

2006-11-13

How to Cite

Bickii, J., Tchouya, G. R. F., Tchouankeu, J. C., & Tsamo, E. (2006). THE ANTIPLASMODIAL AGENTS OF THE STEM BARK OF ENTANDROPHRAGMA ANGOLENSE (MELIACEAE). African Journal of Traditional, Complementary and Alternative Medicines, 4(2), 135–139. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/186

Issue

Vol. 4 No. 2 (2007)

Section

Research Papers

License

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