GENERAL ACTEOSIDE OF REHMANNIAE LEAVES IN THE TREATMENT OF PRIMARY CHRONIC GLOMERULONEPHRITIS: A RANDOMIZED CONTROLLED TRIAL

Authors

  • Hong Yu Qiu
  • Wenxing Fan
  • Ping Fu
  • Chuan Zuo
  • Ping Feng
  • Fang Liu
  • Li Zhou
  • Feng Chen
  • Hui Zhong
  • YaPing Liang
  • Mei Shi

Keywords:

Chronic glomerulonephritis, General acteoside of Rehmanniae leaves, Piperazine ferulate, Randomised controlled trials.

Abstract

The prospective, randomised, parallel controlled trial aimed to assess the efficacy and safety of Traditional Chinese Medicine – general acteoside of Rehmanniae leaves compared with piperazine ferulate in the treatment of primary chronic glomerulonephritis. A total of 400 patients diagnosed with primary chronic glomerulonephritis were recruited from outpatient clinics and were randomly assigned to the treatment group (general acteoside of Rehmanniae leaves, two 200mg tablets, bid) or the control group (piperazine ferulate, four 50-mg tablets, bid ). The primary outcome was 24-h urinary protein. Secondary outcome measures included evaluated glomerular filtration rate (eGFR), erythrocyturia, and electrolytes. After 8 weeks of treatment, the treatment group and the control group showed a mean reduction in 24-h proteinuria of 34.81% and 37.66%. The 95% CI of difference of the mean reduction in 24-h proteinuria between the two groups was [-11.50%, 5.80%]. No significant differences were found between the two groups in the erythrocyturia reduction. Neither group showed obvious changes between baseline and 8 weeks in eGFR or electrolytes. Adverse events occurred at a similarly low rate in the treatment group (1.5%) and control group (2.5%, P = 0.7238). Both general acteoside of of primary chronic glomerulonephritis.

Author Biography

Hong Yu Qiu

Department of Nephrology, West China Hospital, Sichuan University, Chengdu Sichuan, P. R. China

Downloads

Published

2013-04-20

How to Cite

Qiu, H. Y., Fan, W., Fu, P., Zuo, C., Feng, P., Liu, F., Zhou, L., Chen, F., Zhong, H., Liang, Y., & Shi, M. (2013). GENERAL ACTEOSIDE OF REHMANNIAE LEAVES IN THE TREATMENT OF PRIMARY CHRONIC GLOMERULONEPHRITIS: A RANDOMIZED CONTROLLED TRIAL. African Journal of Traditional, Complementary and Alternative Medicines, 10(4), 109–115. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1846

Issue

Section

Research Papers

Most read articles by the same author(s)