STUDY ON ANTI-TUMOR EFFECT OF TOTAL GLYCOSIDES FROM RADIX PAEONIAE RUBRA IN S180 TUMOR-BEARING MICE

Authors

  • Wanpeng Xu
  • Wei Zhong
  • Jinlan Liu
  • Hong Liu
  • Bing Zhu

Keywords:

total glycosides of Radix Paeoniae Rubra, S180 sarcoma, IL-2, IL-4

Abstract

The objective of the paper was to study the anti-tumor effect of total glycosides from Radix paeoniae rubra in S180 tumor-bearing mice, and to preliminarily explore its mechanism of action. Mice were made into S180 solid tumor model, grouped and administered with the extracts; tumor inhibition rate was measured by harvesting the tumors, and serum IL-2 and IL-4 levels were measured by taking blood samples. Total glycosides of Radix paeoniae rubra significantly inhibited the growth of tumor cells in tumor-bearing organisms, enhanced the cytotoxic activity of NK cells, and increased the serum IL-2 and IL-4 levels. Total glycosides of Radix paeoniae rubra have some anti-tumor effect in vivo, which might have been accomplished through the regulation of the immune system.

Author Biography

Wanpeng Xu

Department of Colon &Anorectal Surgery, Affiliated Hospital of Weifang Medical University, Weifang, 261031, China

Downloads

Published

2013-03-19

How to Cite

Xu, W., Zhong, W., Liu, J., Liu, H., & Zhu, B. (2013). STUDY ON ANTI-TUMOR EFFECT OF TOTAL GLYCOSIDES FROM RADIX PAEONIAE RUBRA IN S180 TUMOR-BEARING MICE. African Journal of Traditional, Complementary and Alternative Medicines, 10(3), 580–585. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1810

Issue

Vol. 10 No. 3 (2013)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.