ANTIMICROBIAL, WOUND HEALING AND ANTIOXIDANT ACTIVITIES OF ANTHOCEPHALUS CADAMBA

Authors

  • Sanjay Prahalad Umachigi
  • G. S. Kumar
  • K. N. Jayaveera
  • D. V. Kumar Kishore
  • C K. Ashok kumar
  • R. Dhanapal

Keywords:

Antimicrobial activity, Antioxidant, Wound healing, Anthocephalus cadamba

Abstract

Anthocephalus cadamba (Roxb.) Miq. Syn A. chinensis (Lamk) A. Rich (Rubiaceae) is ethnomedicinally widely used in the form of paste by tribe in western Ghats for treating skin diseases. In this context, antimicrobial potential of A. cadamba against a wide range of microorganisms was studied. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied, besides antioxidant activity to understand the mechanism of wound healing. The alchoholic and aqueous extract of this plant showed significant antibacterial and antifungal activity against almost all the organisms: Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and four fungi Candida albicans, Trichophyton rubrum—dermatophyte fungi, Aspergillus niger, Aspergillus flavus and Aspergillus nidulans—systemic fungi, with especially good activity against the dermatophyte (Trichophyton rubrum) and some infectious bacteria (Escherichia coli, Proteus mirabilis and Staphylococcus aureus) with an MIC of 2.5 µg/disc. The results show that A. cadamba extract has potent wound healing capacity as shown from the wound contraction and increased tensile strength. The results also indicated that A. cadamba extract possesses potent antioxidant activity by inhibiting lipid peroxidation and increase in the superoxide dismutase (SOD) and catalase activity.

Author Biographies

Sanjay Prahalad Umachigi

Rural College of Pharmacy, D.S.Road, PO Box-10, Devanahalli-562110, Bangalore Rural Dist, Karnataka, India.

G. S. Kumar

Rural College of Pharmacy, D.S.Road, PO Box-10, Devanahalli-562110, Bangalore Rural Dist, Karnataka, India.

K. N. Jayaveera

Department of Chemistry, Jawaharlal Nehru Technological University College of Engineering, Ananthpur- 01, Andhra Pradesh, India.

D. V. Kumar Kishore

Rural College of Pharmacy, D.S.Road, PO Box-10, Devanahalli-562110, Bangalore Rural Dist, Karnataka, India.

C K. Ashok kumar

SLN College of Pharmacy, Chitoor, AP, India.

R. Dhanapal

Rural College of Pharmacy, D.S.Road, PO Box-10, Devanahalli-562110, Bangalore Rural Dist, Karnataka, India

Downloads

Published

2007-06-10

How to Cite

Umachigi, S. P., Kumar, G. S., Jayaveera, K. N., Kishore, D. V. K., Ashok kumar, C. K., & Dhanapal, R. (2007). ANTIMICROBIAL, WOUND HEALING AND ANTIOXIDANT ACTIVITIES OF ANTHOCEPHALUS CADAMBA. African Journal of Traditional, Complementary and Alternative Medicines, 4(4), 481 –. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/177

Issue

Vol. 4 No. 4 (2007)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.