EXTRACT OF PERILLA FRUTESCENS INHIBITS TUMOR PROLIFERATION OF HCC VIA PI3K/AKT SIGNAL PATHWAY

Authors

  • Ying Wang
  • Xiaoxu Huang
  • Jianming Han
  • Wenling Zheng
  • Wenli Ma

Keywords:

Perilla Frutescens, IK, Tumor Proliferation, HCC, PI3K/AKT

Abstract

In this study, isoegomaketone(IK) was isolated from Perilla frutescens(L.), a Chinese herbal. The effects of IK were examined by cell viability assay, colony formation assay, xenograft tumor assay and western blotting in HCC cells. We found that IK inhibited cell viability, and its administration decreased tumor volume and weight profoundly. The presence of IK(10nmol/l) produced a dramatic decrease of pAkt, while total Akt level was not affected. The data suggested that IK from perilla suppressed HCC tumor growth via blocking PI3K/Akt signaling pathway.

Author Biography

Ying Wang

Institute of Genetic Engineering, Southern Medical University, Tonghe, Guangzhou 510515, P.R. China.

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Published

2012-12-11

How to Cite

Wang, Y., Huang, X., Han, J., Zheng, W., & Ma, W. (2012). EXTRACT OF PERILLA FRUTESCENS INHIBITS TUMOR PROLIFERATION OF HCC VIA PI3K/AKT SIGNAL PATHWAY. African Journal of Traditional, Complementary and Alternative Medicines, 10(2), 251–257. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1725

Issue

Vol. 10 No. 2 (2013)

Section

Research Papers

License

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