ANTIPROLIFERATION EFFECTS OF SELECTED TANZANIA PLANTS

Authors

  • Chun Whan Choi Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion, Suwon 443-766, Republic of Korea
  • Seok Bean Song Gyeongbuk Institute for Bio-industry (GIB), Andong City, Gyeongbuk 760-380, Korea
  • Joa Sub Oh College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan 330-714, Korea/ Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion, Suwon 443-270, Korea
  • Young Ho Kim College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.

DOI:

https://doi.org/10.21010/ajtcam.v12i2.15

Keywords:

Medicinal plants, Cytotoxicity, Erythrophleum zimmermannii (Fabaceae)

Abstract

Background: Plants still remain a prime source of drugs for the treatment of cancer and can provide leads for the development of novel anticancer agents. Our screening of indigenous medicinal plants from Tanzania has led to the identification of the number of anticancer activity. Material and methods: The current study investigates the cytotoxic activity of methanol extracts of one hundred and thirty seven Tanzania plants used locally for the traditional medicine herb using the MTS assay on the HepG2 cell lines. Result 16% of the tested plant extracts showed moderate to strong inhibitory activity with IC50 values ranging from 17.1 ± 1.1 μg/ml to 79.2 ± 0.7 μg/ml ; meanwhile, ten extracts (7.3%) could demonstrate cytotoxic activity with IC50 values less than 27.6 ± 2.0 μg/ml; twelve extracts (8.8%) could demonstrate cytotoxic activity with IC50 values ranging from 30.4 ± 1.6 μg/ml to 79.2 ± 0.7μg/ml. Conclusion : Especially, a methanol extract from the bark extract of Erythrophleum zimmermannii (Fabaceae) was found to be the most cytotoxicity against HepG2 cell lines (IC50 = 17.1 ± 1.1 μg/ml).

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Published

2015-03-07

How to Cite

Choi, C. W., Song, S. B., Oh, J. S., & Kim, Y. H. (2015). ANTIPROLIFERATION EFFECTS OF SELECTED TANZANIA PLANTS. African Journal of Traditional, Complementary and Alternative Medicines, 12(2), 96–102. https://doi.org/10.21010/ajtcam.v12i2.15

Issue

Vol. 12 No. 2 (2015)

Section

Short communications

License

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