ANTIMICROBIAL ACTIVITIES AND TOXICITY OF CRUDE EXTRACT OF THE PSOPHOCARPUS TETRAGONOLOBUS PODS

Authors

  • L. Yoga Latha L. Yoga Latha
  • S. Sasidharan
  • Z. Zuraini
  • S. Suryani
  • L. Shirley
  • S. Sangetha
  • M. Davaselvi

Keywords:

Antimicrobial activities, Artemia salina, Cytotoxicity assay, P. tetragonolobus

Abstract

The extract of the Psophocarpus tetragonolobus pods has been tested for antimicrobial activity in a disk diffusion assay on eight human pathogenic bacteria and two human pathogenic yeasts. The extracts of P. tetragonolobus possessed antimicrobial activity against all tested strains. The ethanolic extract of P. tetragonolobus pods was further tested for in vivo brine shrimp lethality test and in vitro sheep erythrocyte cytotoxic assay. The brine shrimp lethality test exhibited no significant toxicity (LC50=1.88 mg/ml) against Artemia salina, whereas sheep erythrocyte test showed significant toxicity. The reason for haemolysis of erythrocyte was discussed. The P. tetragonolobus extract with high LC50 value signified that this plant is not toxic to human. This result also suggested that the ethanolic extract of P. tetragonolobus pods is potential source for novel antimicrobial compounds.

Author Biographies

L. Yoga Latha L. Yoga Latha

School of Distance Education, Universiti Sains Malaysia, Minden 11800, Pulau Pinang, Malaysia

S. Sasidharan

Biological Sciences, Universiti Sains Malaysia, Minden 11800, Pulau Pinang, Malaysia.

Z. Zuraini

School of Distance Education, Universiti Sains Malaysia, Minden 11800, Pulau Pinang, Malaysia

S. Suryani

School of Distance Education, Universiti Sains Malaysia, Minden 11800, Pulau Pinang, Malaysia

L. Shirley

Biological Sciences, Universiti Sains Malaysia, Minden 11800, Pulau Pinang, Malaysia.

S. Sangetha

Biological Sciences, Universiti Sains Malaysia, Minden 11800, Pulau Pinang, Malaysia.

M. Davaselvi

School of Distance Education, Universiti Sains Malaysia, Minden 11800, Pulau Pinang, Malaysia

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Published

2006-08-28

How to Cite

L. Yoga Latha, L. Y. L., Sasidharan, S., Zuraini, Z., Suryani, S., Shirley, L., Sangetha, S., & Davaselvi, M. (2006). ANTIMICROBIAL ACTIVITIES AND TOXICITY OF CRUDE EXTRACT OF THE PSOPHOCARPUS TETRAGONOLOBUS PODS. African Journal of Traditional, Complementary and Alternative Medicines, 4(1), 59–63. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/159

Issue

Vol. 4 No. 1 (2007)

Section

Research Papers

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