USE OF ANTIFUNGAL SAPONIN SC-2 OF SOLANUM CHRYSOTRICHUM FOR THE TREATMENT OF VULVOVAGINAL CANDIDIASIS: IN VITRO STUDIES AND CLINICAL EXPERIENCES

Authors

  • Armando Herrera-Arellano Facultad de Medicina, Universidad Autónoma del Estado de Morelos (UAEM). Cuernavaca, Morelos, México.
  • Edgar Oliver lópez-Villegas Escuela Nacional de Ciencias Biológicas (ENCB), Departamento de Microbiología, Instituto Politécnico Nacional (IPN). Ciudad de México, México
  • Aida Verónica Rodríguez-Tovar Escuela Nacional de Ciencias Biológicas (ENCB), Departamento de Microbiología, Instituto Politécnico Nacional (IPN)
  • Alejandro Zamilpa Centro de Investigación Biomédica del Sur (CIBIS), Instituto Mexicano del Seguro Social (IMSS). Xochitepec, Morelos. México
  • Enrique Jiménez-ferrer Centro de Investigación Biomédica del Sur (CIBIS), Instituto Mexicano del Seguro Social (IMSS). Xochitepec, Morelos. México
  • Jaime Tortoriello Centro de Investigación Biomédica del Sur (CIBIS), Instituto Mexicano del Seguro Social (IMSS). Xochitepec, Morelos. México
  • María Angeles Martínez-Rivera Escuela Nacional de Ciencias Biológicas (ENCB), Departamento de Microbiología, Instituto Politécnico Nacional (IPN). Ciudad de México, México

Keywords:

Solanum chrysotrichum, saponins, antifungal activity, vulvovaginal candidiasis, alternative therapy.

Abstract

Saponin SC-2 from Solanum chrysotrichum showed antifungal activity, demonstrated in vitro, which inhibited the growth of dermatophytes, and in vivo, to be effective in the treatment against tinea pedis and pityriasis capitis. Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans and other Candida species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinical, randomized, double-blind, and controlled ketoconazole study of ketoconazole was conducted with the aim of assessing the effectiveness and tolerability of an herbal medicinal product containing SC-2, on women with Vulvovaginal candidiasis (VVC). The results exhibited a percentage of therapeutic clinical effectiveness similar to that of ketoconazole (X2, p ≥0.30), but obtained a smaller percentage of mycological effectiveness, and 100% tolerability. In conclusion, saponin SC-2 possesses fungicidale and fungistatic activity on Candida albicans and other multi resistant Candida species, causes morphological changes and fungal death, and it is an alternative therapy for the treatment of VVC.

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Published

2013-03-15

How to Cite

Herrera-Arellano, A., lópez-Villegas, E. O., Rodríguez-Tovar, A. V., Zamilpa, A., Jiménez-ferrer, E., Tortoriello, J., & Martínez-Rivera, M. A. (2013). USE OF ANTIFUNGAL SAPONIN SC-2 OF SOLANUM CHRYSOTRICHUM FOR THE TREATMENT OF VULVOVAGINAL CANDIDIASIS: IN VITRO STUDIES AND CLINICAL EXPERIENCES. African Journal of Traditional, Complementary and Alternative Medicines, 10(3), 410–417. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1574

Issue

Vol. 10 No. 3 (2013)

Section

Review

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