ANTIDIABETIC EFFECT OF CEIBA PENTANDRA EXTRACT ON STREPTOZO-TOCIN-INDUCED NON-INSULIN-DEPENDENT DIABETIC (NIDDM) RATS

Authors

  • Paul Désiré D. Dzeufiet
  • Dieudonné Y. Ohandja
  • Léonard Tédong
  • Emmanuel Acha Asongalem
  • Théophile Dimo
  • Selestin D. Sokeng
  • Pierre Kamtchouing

Keywords:

Ceiba pentandra, Plant extract, Type 2 diabetes, Streptozotocin.

Abstract

The aim of this work was to investigate the effect of daily oral administration of root bark methylene chloride/methanol extract of Ceiba pentandra (Linn) in streptozotocin-induced type-2 diabetic rats, and the effect of this treatment on the physiological and metabolic parameters that are related in diabetic animals. The diabetic rats were separated into four groups and each given the following samples by gavage, daily for 28 days: vehicle (diabetic control), Ceiba pentandra extract at the dose of 40 mg/kg, Ceiba pentandra extract at the dose of 75 mg/kg and glibenclamide (5 mg/kg). All the parameters were also determined in healthy (non diabetic) rats for comparison. The methylene chloride/methanol extract of Ceiba pentandra treatment significantly reduced the intake of both food and water as well as the levels of blood glucose, serum cholesterol, triglyceride, creatinine and urea, in comparison with diabetic controls. The treatment also improves impaired glucose tolerance but no effect was observed in the level of hepatic glycogen. The effect of Ceiba pentandra (40 mg/kg) was more prominent when compared to glibenclamide in lowering blood glucose, with the added benefit of considerably reducing serum cholesterol and triglyceride concentrations. The results of this experimental animal study indicated that Ceiba pentandra possesses antidiabetic activity; and thus is capable of ameliorating hyperglycaemia in streptozotocin-induced type-2 diabetic rats and is a potential source for isolation of new orally active agent(s) for anti-diabetic therapy.

Author Biographies

Paul Désiré D. Dzeufiet

Department of Animal Physiology, Faculty of Science , University of Yaounde I P.O Box 812 Yaounde Cameroon,

Dieudonné Y. Ohandja

Department of Animal Physiology, Faculty of Science , University of Yaounde I P.O Box 812 Yaounde Cameroon,

Léonard Tédong

Department of Animal Physiology, Faculty of Science , University of Yaounde I P.O Box 812 Yaounde Cameroon,

Emmanuel Acha Asongalem

Department of Physiological Sciences, Faculty of Medicine and Biomedical Sciences, Pharmacology and Toxicology Unit, University of Yaounde I P.O Box 8283 Yaounde Cameroon

Théophile Dimo

Department of Animal Physiology, Faculty of Science , University of Yaounde I P.O Box 812 Yaounde Cameroon,

Selestin D. Sokeng

Department of Biological Sciences, Faculty of Sciences, University of Ngaoundere, P.O Box 454 Ngaoundere Cameroon

Pierre Kamtchouing

Department of Animal Physiology, Faculty of Science , University of Yaounde I P.O Box 812 Yaounde Cameroon,

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Published

2006-08-28

How to Cite

Dzeufiet, P. D. D., Ohandja, D. Y., Tédong, L., Asongalem, E. A., Dimo, T., Sokeng, S. D., & Kamtchouing, P. (2006). ANTIDIABETIC EFFECT OF CEIBA PENTANDRA EXTRACT ON STREPTOZO-TOCIN-INDUCED NON-INSULIN-DEPENDENT DIABETIC (NIDDM) RATS. African Journal of Traditional, Complementary and Alternative Medicines, 4(1), 47–54. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/157

Issue

Vol. 4 No. 1 (2007)

Section

Research Papers

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