IN VIVO ACTIVITY OF (8-HYDROXYMETHYLEN)-TRIEICOSANYL ACETATE AGAINST TRYPANOSOMA CRUZI DURING ACUTE PHASE OF THE INFECTION

Authors

  • Matilde Jiménez-Coello
  • Karla Yolanda Acosta-Viana
  • Maria Salud Pérez G.
  • Eugenia del S. Guzmán-Marín

Keywords:

Chagas’ disease, antiprotozoal, in vivo, Senna villosa.

Abstract

The antiprotozoal activity in vivo against Trypanosoma cruzi of (8-hydroxymethylen)-trieicosanyl acetate was evaluated in BALB/c mice during the acute phase of Chagas’ disease (15 days after infection). Animals were treated during 15 days at doses of 16.8 and 33.6 µg/g, reduced parasitemia of 77.6 and 64.1% was observed respectively, in comparison with positive control mice (allopurinol 8.5 µg/g) which reduced only 29.7%. Also, amastigote nests in cardiac tissue were significant reduced in treated mice groups. The regression of effect induced after the suppression of the treatment with the compound was evaluated; animals were infected and simultaneously began the treatment with the compound during 20 days (16.8 and 33.6 µg/g). Mice were monitored after the end of the treatment for one more week. A good antitrypanosomal response was observed (66.1 and 68.9% less than untreated mice) during treatment, but 8 days after suspension of treatment, parasitemia level increased, reducing only 58.6 and 56.29 % respectively in treated animals compared with no treated.

Author Biography

Matilde Jiménez-Coello

Laboratorio de Biologia Celular, CIR ‘‘Dr. Hideyo Noguchi’’. Universidad Autonoma de Yucatán. Ave. Itzaes # 490 x 59, Centro. C. P. 97000. Merida Yucatan, Mexico.

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Published

2011-04-27

How to Cite

Jiménez-Coello, M., Acosta-Viana, K. Y., Pérez G., M. S., & Guzmán-Marín, E. del S. (2011). IN VIVO ACTIVITY OF (8-HYDROXYMETHYLEN)-TRIEICOSANYL ACETATE AGAINST TRYPANOSOMA CRUZI DURING ACUTE PHASE OF THE INFECTION. African Journal of Traditional, Complementary and Alternative Medicines, 8(5S), 198–207. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1334

Issue

Section

Research Papers

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