INVESTIGATION OF THE ANTITRYPANOSOMAL ACTIVITY OF BUCHHOLZIA CORIACEA SEED EXTRACT AGAINST A FIELD STRAIN OF TRYPANOSOMA CONGOLENSE

Authors

  • Nwakaego Ernestina Nweze University of Nigeria, Nsukka
  • Boniface Maduka Anene Department of Veterinary Medicine Faculty of Veterinary Medicine University of Nigeria, Nsukka.
  • Isaac Uzoma Asuzu Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka.

Keywords:

Trypanosoma congolense, Buchholzia coriacea, Antitrypanosomal activity

Abstract

The antitrypanosomal activity of the methanol extract of Buchholzia coriacea seed against a field strain of Trypanosoma congolense was investigated using experimentally infected mice of both sexes. Monitoring of parasitaemia was by the rapid matching technique. When parasitaemia was approximately log 7.8 (63 x 106 parasites/ml), treatment with graded doses of the extract (250, 500 and 1000 mg/kg) was instituted for 5 consecutive days. Diminazene diaceturate (Dimivet® SKM Pharma Pvt. Ltd.) was given at 3.5 mg/kg i.p. to the positive control mice. There was no significant difference between the PCV of the extract-treated and untreated animals. Three days post-treatment with diminazene diaceturate there was aparasitaemia however, a 50 % relapse rate was recorded in the same group later. The methanol extract of Buchholzia coriacea seeds showed no antitrypanosomal activity in mice infected with Trypanosoma congolense at the doses tested.

Author Biographies

Nwakaego Ernestina Nweze, University of Nigeria, Nsukka

Veterinary Medicine Lecturer II

Boniface Maduka Anene, Department of Veterinary Medicine Faculty of Veterinary Medicine University of Nigeria, Nsukka.

Veterinary Medicine Professor

Isaac Uzoma Asuzu, Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka.

Veterinary Physiology & Pharmacology Professor

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Published

2011-04-21

How to Cite

Nweze, N. E., Anene, B. M., & Asuzu, I. U. (2011). INVESTIGATION OF THE ANTITRYPANOSOMAL ACTIVITY OF BUCHHOLZIA CORIACEA SEED EXTRACT AGAINST A FIELD STRAIN OF TRYPANOSOMA CONGOLENSE. African Journal of Traditional, Complementary and Alternative Medicines, 8(5S), 175–180. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1289

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Section

Research Papers