POTENTIAL PROTECTIVE EFFECT OF SOME PLANT EXTRACTS AGAINST CARBON TETRACHLORIDE – INDUCED HEPATOTOXICITY

Authors

  • a. h. Atta
  • S. M. Nasr
  • S. M. Mouneir

Keywords:

hepatoprotective, medicinal plants, Plantago major, Diplotaxis

Abstract

Plantago major seeds, Diplotaxis acris and Schouiwa thebaica methanol extracts were evaluated for their potential hepatoprotective effects against carbon tetrachloride induced hepatic damage model. Preliminary phytochemical studies were carried out to elucidate their components. Oral administration of the methanol extract (1000 mg kg-1) of Plantago major seeds, Diplotaxis acris and Schouiwa thebaica significantly (P< 0.05) attenuated the CCl4-induced hepatotoxicity. This was indicated by the tendency of serum enzyme activities to return toward the normal values. Moreover the histopathological changes of liver tissues induced by CCl4 were moderate to mild in methanol extract-pretreated rats. No toxic symptoms were reported in rats receiving methanol extract at doses up to 2.5 g kg-1. Unsaturated sterols and/or triterpenes, tannins, flavonoids and carbohydrates and/or glycosides were the major active constituents of the tested plants.

Author Biographies

a. h. Atta

Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211

S. M. Nasr

arasitology and Animal Diseases Department, National Research Center, Giza, Egypt

S. M. Mouneir

Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211

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Published

2006-03-27

How to Cite

Atta, a. h., Nasr, S. M., & Mouneir, S. M. (2006). POTENTIAL PROTECTIVE EFFECT OF SOME PLANT EXTRACTS AGAINST CARBON TETRACHLORIDE – INDUCED HEPATOTOXICITY. African Journal of Traditional, Complementary and Alternative Medicines, 3(3), 1–9. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/114

Issue

Vol. 3 No. 3 (2006)

Section

Research Papers

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