EVALUATION OF PISTACIA LENTISCUS FATTY OIL EFFECTS ON GLYCEMIC INDEX, LIVER FUNCTIONS AND KIDNEY FUNCTIONS OF NEW ZEALAND RABBITS

Authors

  • Zouhir Djerrou Pharmacotoxicology Laboratory. department of veterinary sciences .university of Constantine. Algeria.
  • Youcef Hamdi Pacha Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria
  • Abd el Malik Belkhiri Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria
  • Hadria Djaalab Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria
  • Foula Riachi Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria
  • Mennouba Serakta Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria
  • Ahmed Boukeloua Pharmacotoxicology Laboratory.
  • Zineb Maameri Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria

Keywords:

Pistacia lentiscus, fatty oil, glycemic index, LFT, RFT, rabbits

Abstract

Pistacia lentiscus fatty oil (PLFO) is a well known natural remedy in eastern Algeria folk medicine. It is widely used in the treatment of respiratory disorders and dermal burns. The present study has been carried out to investigate effects of this oil on fasting glucose and some functional parameters of the liver and kidney in white male New Zealand rabbits (Initial mean weight 1.95 Kg). PLFO was applied to tested rabbits (PLFO group) via rectal route, once daily 5-day per week, for six consecutive weeks at the dose of 1ml/Kg body weight. The same number of animals (n=6) was not treated and served as control (CRL group). The results showed that PLFO was tolerated by rectal route. No significant differences were observed in body weights of the two groups. Biochemical analysis showed that aspartate transaminase (AST) and alanine transaminase (ALT) were significantly decreased in blood plasma at (P< 0.05) and (P< 0.01) respectively in PLFO group (Mann-Whitney test). On the other hand, the fasting glucose level (GLU) was significantly increased (Mann-Whitney test, P< 0.05), while the rest of the tested parameters (Albumin, total proteins, creatinine, urea) was not significantly affected. However, these variations have not biologic signification toxicity. The study concludes that PLFO is tolerable via rectal route; it is safe with no adverse effect on liver functions and renal functions with possible anti-glycogenesis activity.

Author Biographies

Zouhir Djerrou, Pharmacotoxicology Laboratory. department of veterinary sciences .university of Constantine. Algeria.

Veterinary sciences department, Faculty of sciences, university Mentouri Constantine.Algeria.

Youcef Hamdi Pacha, Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria

Veterinary sciences department, Faculty of sciences, university Mentouri Constantine.Algeria.

Abd el Malik Belkhiri, Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria

Department of pharmacy, Constantine University, Algeria.

Hadria Djaalab, Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria

Veterinary sciences department, Faculty of sciences, university Mentouri Constantine.Algeria.

Foula Riachi, Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria

Veterinary sciences department, Faculty of sciences, university Mentouri Constantine.Algeria.

Mennouba Serakta, Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria

Veterinary sciences department, Faculty of sciences, university Mentouri Constantine.Algeria.

Ahmed Boukeloua, Pharmacotoxicology Laboratory.

Department of biology, University of Oum Bouaghi.

Zineb Maameri, Pharmacotoxicology Laboratory. Mentouri Constantine University, Algeria

Department of biology, Mentouri Constantine University, Algeria

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Published

2011-05-06

How to Cite

Djerrou, Z., Hamdi Pacha, Y., Belkhiri, A. el M., Djaalab, H., Riachi, F., Serakta, M., Boukeloua, A., & Maameri, Z. (2011). EVALUATION OF PISTACIA LENTISCUS FATTY OIL EFFECTS ON GLYCEMIC INDEX, LIVER FUNCTIONS AND KIDNEY FUNCTIONS OF NEW ZEALAND RABBITS. African Journal of Traditional, Complementary and Alternative Medicines, 8(5S), 214–219. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1134

Issue

Vol. 8 No. 5S (2011)

Section

Research Papers

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