TY - JOUR AU - Leylabadlo, Hamed Ebrahimzadeh AU - Pourlak, Tala AU - bialvaei, Abed Zahedi AU - Aghazadeh, Mohammad AU - Asgharzadeh, Mohammad AU - Kafil, Hossein Samadi PY - 2017/06/08 Y2 - 2024/03/29 TI - EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING GRAM NEGATIVE BACTERIA IN IRAN JF - African Journal of Infectious Diseases (AJID) JA - Afr. J. Infect. Dis. VL - 11 IS - 2 SE - Review DO - 10.21010/ajid.v11i2.6 UR - https://journals.athmsi.org/index.php/AJID/article/view/4790 SP - 39-53 AB - Background: The emergence and spread of extended spectrum β-lactamase (ESBL)-producing Gram- negative bacteria(GNB), particularly in Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa, have increased all overthe world. ESBLs are characterized by their ability to hydrolyze β-lactams, early cephalosporins, oxyimino-thiazolylcephalosporins, and monobactams, but not cephamycins or carbapenems. The rate of nosocomial infections caused byESBL-producing GNB in Asia Pacific has increased and several studies have identified their prevalence in the region. Theaim of this study is to review the prevalence of ESBL-producing GNB in the West Asia and the Middle East with aparticular focus on Iran.Materials and Methods: The available evidence from various studies (Microbia and clinical studies, retrieved from thePubMed, and Scopus databases) regarding the ESBL producing Gram negative bacteria in Iran were evaluated.Results: In almost all parts of the country, high resistance has been observed, especially in the central part of Iran. Up to89.8% Escherichia coli, 72.1% Klebsiella pneumonia, 84.2% Acinetobacter baumannii, and 83.8% Pseudomonasaeruginosa isolates are ESBL positive.Conclusion: The present study showed the increasing prevalence of ESBLs in different regions of Iran, which could beuseful to strategic policy towards reducing reduce their prevalence. ER -