ARTESUNATE PLUS AMODIAQUINE (AS+AQ) VERSUS ARTEMETHER -LUMEFANTRINE (AL) FOR THE TREATMENT OF UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA IN SUB-SAHARAN AFRICA-A META-ANALYSIS

Authors

  • Shaibu O. Bello Department of Pharmacology, Usmanu Danfodiyo University, Sokoto
  • Aminu Chika Department of Pharmacology, Usmanu Danfodiyo University, Sokoto
  • AbdulGafar O. Jimoh Department of Pharmacology, Usmanu Danfodiyo University, Sokoto

Keywords:

Artemisinin combination therapy, Malaria, Artemether, Artesunate, Amodiaquine, lumefanthrine, plasmodium, meta-analysis

Abstract

The purpose of this study is to summarize the available data on the efficacy of Artesunate plus Amodiaquine (AS+AQ) versus Artemether -Lumefantrine (AL) for the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa using uncorrected parasitaemia as a clinically relevant endpoint. Studies and conference abstracts identified through Pubmed, Medline, Embase, Ansinet, AJOL, Bioline, Cochrane Infectious Diseases Group trials register, The Cochrane Controlled Trials Register, Science Citation Index, Lilacs, African Index Medicus, Clusty, Google, Yahoo and Microsoft search engines. Randomized controlled clinical trials comparing Artesunate-Amodiaquine versus Artemether–Lumefantrine, in Sub-Saharan Africa from January 2004 to June 2009, and which had at least 30 patients per study arm. The authors independently applied the inclusion criteria, assessed methodological quality and extracted data into a pre-designed form. The outcome of interest was uncorrected day 28 parasitological failure. Data were then checked for agreement and double entered into RevMan version 5 for further analyses. Fifteen trials (4265 participants) met the inclusion criteria. Day 28 parasitological failure was lower for AL (286 of 2201 participants or 13.0 % failures) when compared with AS+AQ (446 of 2424 participants or 18.4% failures). The relative risk of parasitological failure with AS+AQ was higher when compared with AL (RR 1.65, 95% CI, 1.18-2.32). There were significant heterogeneity and inconsistencies in the studies. AL appears more effective at avoiding parasitological failure at days 28 than AS+AQ.

Author Biographies

Shaibu O. Bello, Department of Pharmacology, Usmanu Danfodiyo University, Sokoto

Senior Lecturer, Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria

Aminu Chika, Department of Pharmacology, Usmanu Danfodiyo University, Sokoto

Lecturer II , Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria

AbdulGafar O. Jimoh, Department of Pharmacology, Usmanu Danfodiyo University, Sokoto

Lecturer II , Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria

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Published

2010-02-11

How to Cite

Bello, S. O., Chika, A., & Jimoh, A. O. (2010). ARTESUNATE PLUS AMODIAQUINE (AS+AQ) VERSUS ARTEMETHER -LUMEFANTRINE (AL) FOR THE TREATMENT OF UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA IN SUB-SAHARAN AFRICA-A META-ANALYSIS. African Journal of Infectious Diseases (AJID), 4(2), 20–28. Retrieved from https://journals.athmsi.org/index.php/AJID/article/view/986

Issue

Section

Review