ANTI-INFLAMMATORY AND METABOLIC EFFECTS OF COFFEA CANEPHORA EXTRACT IN DIABETIC RATS: INSIGHTS FROM TNF-Α REDUCTION AND INSULIN SENSITIVITY INDICES

Authors

  • Jekson Martiar Siahaan Institut Kesehatan Deli Husada Deli Tua
  • Endy Juli Anto
  • Tengku Muhammad Fauzi
  • Sumihar MR Pasaribu Department of Biochemistry, Faculty of Medicine, Institut Kesehatan Deli Husada Deli Tua, Indonesia;
  • Hana Isal Salina Ginting Department of Parasitology, Faculty of Medicine, Institut Kesehatan Deli Husada Deli Tua, Indonesia
  • Friska Ernita Sitorus Department of Medical-Surgical Nursing, Faculty of Nursing, Institut Kesehatan Deli Husada Deli Tua, Indonesia
  • Hariati Hariati Department of Medical-Surgical Nursing, Faculty of Nursing, Institut Kesehatan Deli Husada Deli Tua, Indonesia
  • Firdaus Fahdi Department of Pharmacy, Faculty of Pharmacy, Institut Kesehatan Deli Husada Deli Tua, Indonesia
  • Peny Ariani Faculty of midwifery, Institut Kesehatan Deli Husada Deli Tua, Indonesia
  • Untung Sujianto Department of Nursing, Faculty of of Medicine, Universitas Diponegoro, Semarang, Indonesia;
  • Rostime Hermayerni Simanullang Department of Nursing, Faculty of Nursing, Universitas Murni Teguh, Medan, Indonesia;
  • Suryati Sinurat Department of Public Health, Faculty of Medicine, Universitas Methodist Indonesia, Medan, Indonesia;
  • Jadeny Sinatra Department of Anesthesiology, Faculty of Medicine, Universitas Methodist Indonesia, Medan, Indonesia;
  • Hadyanto Lim Department of Pharmacology, Faculty of Medicine, Universitas Methodist Indonesia, Medan, Sumatra Utara, Indonesia.

DOI:

https://doi.org/10.21010/Ajidv19n2S.5

Keywords:

Coffea canephora var. robusta, Glucose Homeostasis, Antiinflammatory

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by Insulin resistance, hyperglycemia, and systemic inflammation. Coffea canephora var. robusta contains bioactive compounds with potential antihyperglycemic and anti-inflammatory effects. This study aimed to evaluate the metabolic and inflammatory effects of its ethanolic extract in a rat model of T2DM.

Materials and Methods: Forty-four male Wistar rats were randomized into 11 groups, including normal, diabetic controls, and treatment groups receiving ethanolic or ethyl acetate extracts (100–400 mg/kgBW). T2DM was induced using a high-fat diet and streptozotocin ± nicotinamide. Outcomes measured were fasting blood glucose (FBG), glucose-lowering percentage (%GL), fasting insulin resistance index (FIRI), quantitative insulin sensitivity check index (QUICKI), and TNF-α levels.

Results: The 400 mg/kgBW ethanolic extract group showed a significant reduction in FBG (p = 0.017), percentage of glucose lowering (p = 0.000), TNF-α levels (p = 0.000), and body weight (p = 0.000) compared to diabetic controls, indicating improved metabolic regulation.

Conclusion: The ethanolic extract of C. canephora improves glycemic control, enhances insulin sensitivity, and reduces inflammation in T2DM rats, supporting its potential for future clinical validation.

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Published

2025-10-17

How to Cite

Siahaan, J. M., Anto, E. J., Fauzi, T. M., Pasaribu, S. M., Ginting, H. I. S., Sitorus, F. E., Hariati, H., Fahdi, F., Ariani, P., Sujianto, U., Simanullang, R. H., Sinurat, S., Sinatra, J., & Lim, H. (2025). ANTI-INFLAMMATORY AND METABOLIC EFFECTS OF COFFEA CANEPHORA EXTRACT IN DIABETIC RATS: INSIGHTS FROM TNF-Α REDUCTION AND INSULIN SENSITIVITY INDICES. African Journal of Infectious Diseases (AJID), 19(2S), 37–44. https://doi.org/10.21010/Ajidv19n2S.5

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Vol. 19 No. 2S (2025): Supplementary

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