EFFECTIVENESS OF HERBAL AND CONVENTIONAL MANAGEMENT INTERVENTIONS OF HEPATITIS B VIRUS

Authors

  • Julius John ADEBAYO Department of Economics, Lead City University, Ibadan, Nigeria
  • Lawal Odula IBRAHEEM Bio-medicinal Research Centre, Forestry Research Institute of Ibadan, Nigeria
  • Beauty Etinosa OMORUYI Cape Peninsula University of Technology
  • Vincent Ifeanyi OKUDOH Department of Biotechnology and Consumer Science, Cape Peninsula University of Technology, Cape Town, South Africa.

DOI:

https://doi.org/10.21010/Ajid%20v19i1.

Keywords:

Key-words: Hepatitis B; cost-effectiveness; conventional management; phytomedicine; quality-adjusted life-years (QALYs).

Abstract

Background: Liver inflammation caused by the Hepatitis B virus (HBV) could become chronic and unresolved if untreated. Prevention and management of the disease are through vaccination and other conventional interventions. This study evaluated the cost-effectiveness of herbal management (HM) and conventional pharmaceutical management (PM) interventions in treating HBV.

Materials and Methods: A purposive sampling technique was used to administer questionnaires at the University College Hospital (UCH) and Total Healthcare Diagnostic Centre (THDC). Data collection was according to a EuroQol (EQ -5D), while descriptive and inferential analyses were performed.

Results: Findings revealed a high prevalence of HBV among females from ages 26 to 50. The majority discovered their health status through free HBV tests. Other than cost-effective interventions, about 73% of cases adopted HM to manage the disease. A significant difference (P<0.00) was observed in the correlation analysis of the current health status of respondents and the intervention management adopted. correlation analysis of the current health status of respondents was significantly different (P<0.01) against the intervention management adopted (P<0.00).

Conclusion: The minister of health should emphasize HBV regular screening, subsidized viral load test and free vaccination in both public and private healthcare centres.

References

Abebaw TA, Aderaw Z and Gebremichael B (2017). Hepatitis B virus vaccination status and associated factors among health care workers in Shashemene Zonal Town, Shashemene, Ethiopia: A cross-sectional study. BMC Research Notes, 10:260. https://doi.org/10.1186/s13104-017-2582-0.

Ajuwon BI, Yujuico I, Roper K, Richardson A, Sheel M and Lidbury B (2021). Hepatitis B virus infection in Nigeria: A systematic review and meta-analysis of data published between 2010 and 2019. BMC Infectious Diseases, 21:1120. https://doi.org/10.1186/s12879-021-06800-6.

Awomukwu DA, Nyananyo BL, Onukwube ND, (2014). Comparative phytochemical constituents and pharmacognistic importance of the vegetative organs of some Phyllanthus species in South-Eastern Nigeria. International Journal of Modern Botany, 4(2):29-39. https://doi.org/10.5923/j.ijmb.20140402.01.

Belopolskaya M, Avrutin V, Kalinina O, Dmitriev A, and Gusev D. Chronic hepatitis B in pregnant women: Current trends and approaches. World Journal of Gastroenterology. 2021; 27(23):3279-3289. https://doi.org/10.3748/wjg.v27.i23.3279.

Bonolo BP, Motswedi A, Irene G, (2023). High Prevalence of hepatitis B virus infection among people with HIV in rural and Periurban communities in Botswana. Open Forum Infectious Diseases, 10 (1):ofac707. https://doi.org/10.1093/ofid/ofac707.

Chang JM and Huang KL (2017). Complementary and alternative therapies in the treatment of chronic. Hepatitis B Annual, 4(1):72-106. https://doi.org/10.4103/0972-9747.45091.

Daka D, Hailemeskel G and Fenta DA (2022). Prevalence of Hepatitis B Virus infection and associated factors among female sex workers using respondent-driven sampling in Hawassa City, Southern Ethiopia. BMC Microbiology, 22(1):37. https://doi.org/10.1186/s12866-022-02444-x.

Egamberdieva D, Jabborova D, Babich S, (2021). Antimicrobial activities of herbal plants from Uzbekistan against human pathogenic microbes. Environmental Sustainability, 4:87-94. https://doi.org/10.1007/s42398-020-00147-5.

Freeland C, Racho R, Kamischke M (2021). Health-related quality of life for adults living with hepatitis B in the United States: A qualitative assessment. Journal of Patient-Reported Outcomes, 10:5(1):121. https://doi.org/ 10.1186/s41687-021-00398-8.

Gaetan L, Eloi R, Verrier MN and Thomas FB (2021). Hepatitis B virus-host interactions and novel targets for viral cure. Current Opinion in Virology, 49:41-51. https://doi.org/10.1016/j.coviro. 2021.04.009.

Hong X, Luckenbaugh L, Perlman D, (2021). Characterization and application of precore/core-related antigens in animal models of hepatitis B virus infection. Hepatology, 74(1):99-115. https://doi.org/10.1002/hep.31720.

Hou JL, Zhao W, Lee C, (2020). Outcomes of long-term treatment of chronic HBV infection with entecavir or other agents from a randomized trial in 24 countries. Journal of Clinical Gastroenterology and Hepatology, 18(2):457-467. https://doi.org/10.1016/j.cgh.2019.07.010.

Hye WL, Jae S and Sang HA (2020). Hepatitis B virus cure: Targets and future therapies. International Journal of Molecular Science, 22(1): 213. https://doi.org/10.3390/ijms22010213.

Kassaw B, Abera N, Legesse T, (2022). Sero-prevalence and associated factors of hepatitis B virus among pregnant women in Hawassa city public hospitals, Southern Ethiopia: Cross-sectional study design. SAGE Open Medicine, https://doi.org/ 10.1177/20503121221140778.

Khalid FK, Rasheed NA, Hussein NR and Naqid IA (2022). A study of HBV infection and its risk factors in pregnant women in Zakho city, Iraq. PLoS ONE, 17(8):e0273362. https://doi.org/10.1371/journal.pone.0273362.

Ma T, Lee LY, Aw MM and Lee GH (2020). Cost-effectiveness analysis of antiviral treatment for pregnant women with high viral load to prevent hepatitis B virus vertical transmission. Singapore Medical Journal, 61(1):24-27. https://doi.org/10.11622/smedj.2019092.

Mohamed EA, Giama NH, Shaleh HM, (2020). Knowledge, attitudes, and behaviors of viral hepatitis among recent African immigrants in the United States: A community based participatory research qualitative study. Frontiers in Public Health, 8:25. https://doi.org/10.3389/fpubh.2020.00025.31.

Mohammad ASF, AL-Mahtab M, Khan S, Yoshida O and Hiasa Y (2022). Elimination of hepatitis by 2030: Present realities and future projections. Infectious Disease and Immunity, 2(1):3-8. https://doi.org/10.1097/ID9.0000000000000028.

Mohammed H, Eshetie A and Melese D (2022). Prevalence of hepatitis B virus and associated risk factors among adults’ patients at Dessie referral and Kemadults’neral hospitals in Northeastern Ethiopia. Health Science Report, 5(3):e659. https://doi.org/10.1002/hsr2.659.

Moonsamy S, Suchard M, Pillay P and Prabdial-Sing N (2022). Prevalence and incidence rates of laboratory-confirmed hepatitis B infection in South Africa, 2015 to 2019. BMC Public Health, 22(1):29. https://doi.org/10.1186/s12889-021-12391-3.

Musa BM, Bussell S, Borodo MM, Samaila AA and Femi OL (2015). Prevalence of hepatitis B virus infection in Nigeria, 2000-2013: A systematic review and meta-analysis. Nigerian Journal of Clinical Practice, 18(2):163-172. http://dx.doi.org/10.4103/1119-3077.151035.

Nimat BI and Adedapo A (2020). Knowledge, attitude and practice of treatment of Hepatitis-B by natural medicine practitioners in South-West Nigeria. Journal of Primary Health Care and General Practice, 4: 1- 031.

Nsibirwa S, Anguzu G, Kamukama S, (2020). Herbal medicine use among patients with viral and non-viral Hepatitis in Uganda: Prevalence, patterns and related factors. BMC Complementary Medicine and Therapy, 20:169. https://doi.org/10.1186/s12906-020-02959-8.

Prieto L and Sacristan JA (2023). Problems and solutions in calculating quality-adjusted life years (QALYs). Health Qual Life Outcomes, 1:80. https://doi.org/10.1186/1477-7525-1-80.

Ruggieri A, Gagliardi MC and Anticoli S (2018). Sex-dependent outcome of hepatitis B and C viruses’ infections: Synergy of sex hormones and immune responses? Frontiers in Immunology, 9: 2302.

Sagnelli E, Macera M, Russo A, Coppola N and Sagnelli C (2020). Epidemiological and etiological variations in hepatocellular carcinoma. Infection, 48:7-17. https://doi.org/10.1007/s15010-019-01345-y.

Samuelson PA (1938). A note on the pure theory of consumer’s behavior. Economical, 5:61-71. https://doi.org/10.2307/2548836.

Sano T, Amano K, Ide T, (2020). Short‑term efficacy after switching from adefovir dipivoxil and tenofovir disoproxil fumarate therapy to tenofovir alaferamide for chronic hepatitis B. Biomedical Reports, 14(1):12. https://doi.org/10.3892/br.2020.1388.

Schillie S, Vellozzi C, Reingold A, et al (2018). Prevention of hepatitis B virus infection in the United States: Recommendations of the advisory committee on immunization practices. The Morbidity and Mortality Weekly Report (MMWR), 67(1):1-31. https://doi.org/10.15585/mmwr.rr6701a1.

Schmit N, Nayagam S, Lemoine M, (2023). Cost-effectiveness of different monitoring strategies in a screening and treatment programme for hepatitis B in The Gambia. Journal of Global Health, 13:04004. https://doi.org/10.7189/jogh.13.04004.

Sonderup MW and Spearman CW (2022). Global disparities in Hepatitis B elimination- A focus on Africa. Viruses, 14(1):82. https://doi.org/10.3390/v14010082.

Tassachew Y, Abebe T, Belyhun Y, (2022). Prevalence of HIV and its co-infection with Hepatitis B/C virus among chronic liver disease patients in Ethiopia. Hepatic Medicine, 14:67-77. https://doi.org/10.2147/HMER.S365443.

Terrault NA, LOK ASF, McMahon BJ, Chang KM, Hwang JP, Jonas MM, Brown RS, Bzowej NH and Wong JB (2018). Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD hepatitis B guidance. Hepatology, 67(4):1560-1599. https://doi.org/10.1002/hep.29800.

Wong RJ and Khalili M (2020). A patient-centreed hepatitis B virus (HBV) educational intervention improves HBV care among underserved safety-net populations. Journal of Clinical Gastroenterology, 54(7):642-647.https://doi.org/10.1097/MCG.0000000000001276.

Xu X, Wu C, Jiang L,. Cost-effectiveness of hepatitis B mass screening and management in high-prevalent rural China: A model study from 2020 to 2049. Int J Health Policy Manag. 2022; 11(10):2115-2123. https://doi.org/10.34172/ijhpm.2021.126

Downloads

Published

2024-10-25

How to Cite

ADEBAYO , J. J., IBRAHEEM , L. O., OMORUYI , B. E., & OKUDOH , V. I. (2024). EFFECTIVENESS OF HERBAL AND CONVENTIONAL MANAGEMENT INTERVENTIONS OF HEPATITIS B VIRUS. African Journal of Infectious Diseases (AJID), 19(1), 1–12. https://doi.org/10.21010/Ajid v19i1.

Issue

Section

Articles