June 18, 2018
- HIV / AIDS,
- bio impedance,
- body weight gain.
How to Cite
Montalvo, R., Bernabe-Ortiz, A., Kirwan, D. E., & Gilman, R. H. (2018). BIOIMPEDANCE MARKERS AND TUBERCULOSIS OUTCOME AMONG HIV-INFECTED PATIENTS. African Journal of Infectious Diseases (AJID), 12(2), 47-54. https://doi.org/10.21010/Ajid.v12i2.8
Background: The changes in body composition markers (weight, fat mass, lean mass, and BMI) over time can be
associated with TB treatment outcome among HIV-infected patients. The aim of this study was to investigate whether
changes in fat mass and lean mass were associated with the treatment response among patients with HIV infection and
Materials and Methods: This was a prospective cohort study. Data from HIV-infected patients commencing TB
therapy were analyzed. This included body weight measurement using bioimpedance equipment at baseline, one
month, and two months after starting TB treatment.
Results: The study was conducted in 125 patients, 17 patients (13.6%) died during treatment, of which 5 died during
the first month of treatment, 4 during the second month and 8 after the second month. The group of patients with good
response, increased their weight by 1.3 kg (p <0.001) at the end of the first month of TB treatment and 2.6 kg in the
second month (p <0.001), and body fat increase was 1.2 Kg (p <0.001) and 2.3 kg (p <0.001), the first and second
month respectively. The group of patients who died had lost 2.1 kg fat mass after the first month (p <0.001) and 3.7 kg
in the second month (p <0.001).
Conclusions: Our results show that the weight change during TB treatment (increased fat mass) helps us predict
therapeutic response. Weight loss during the first month of starting therapy should be evaluated thoroughly to identify
the probable cause of treatment failure.