Vol 12 No 2 (2018)
Articles

DETECTION OF HUMAN HERPESVIRUS-8 ANTIGEN IN HIV-INFECTED PATIENTS IN EAST JAVA, INDONESIA

Devi Oktafiani
Doctoral Degree Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia;
Bio
Ni Luh Ayu Megasari
Doctoral Degree Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia;
Bio
Elsa Fitriana
Doctoral Degree Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia;
Bio
Nasronudin Nasronudin
Universitas Airlangga Hospital, Surabaya, Indonesia;
Bio
Maria Inge Lusida
Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia
Bio
Soetjipto Soetjipto
Department of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Bio
Published June 18, 2018
Keywords
  • HHV-8 antigen,
  • HIV-positive,
  • East Java,
  • Indonesia.
How to Cite
Oktafiani, D., Megasari, N. L., Fitriana, E., Nasronudin, N., Lusida, M. I., & Soetjipto, S. (2018). DETECTION OF HUMAN HERPESVIRUS-8 ANTIGEN IN HIV-INFECTED PATIENTS IN EAST JAVA, INDONESIA. African Journal of Infectious Diseases (AJID), 12(2), 43-46. https://doi.org/10.21010/Ajid.v12i2.7

Abstract

Background: Co-infection of human herpesvirus-8 (HHV-8) in HIV-positive people might cause Kaposi's sarcoma. Early detection of HHV-8 may prevent the onset of clinical manifestations. In Indonesia, detection of HHV-8 antigen in HIVpositive patients has yet to be reported. The intention of this research was to examine the presence of HHV-8 antigen in HIV-positive patients in East Java, Indonesia. Material and Methods: 103 serum samples were collected from HIV-positive patients in Surabaya and Tulungagung, East Java, Indonesia. Serums were then tested for the presence of HHV-8 antigen by using sandwich ELISA. Results: Human Herpesvirus-8 antigen was detected in 15 samples (14.5%). The presence of HHV-8 infection in HIVpositive patients did not present differently in males and females and among different age groups. Human immunodeficiency virus-positive serum samples were collected from 23 homosexual men, 25 intravenous drug users (IVDUs) and 52 heterosexuals. In the male homosexual group, HHV-8 antigen was detected in 21.7% (5/23) of the samples, while in the intravenous drug user group (IVDUs), 16% (4/25) of the samples were found to have HHV-8 antigen. Conclusion: This research found the presence of HHV-8 antigen in 14.5% of patients in East Java, Indonesia. It is recommended that patients with a positive result should receive further examination to detect any clinical manifestations related to HHV-8 infection, especially in the form of Kaposi’s sarcoma lesions, so that the illness can be appropriately managed.