June 18, 2018
- HHV-8 antigen,
- East Java,
How to Cite
Oktafiani, D., Megasari, N. L., Fitriana, E., Nasronudin, N., Lusida, M. I., & Soetjipto, S. (2018). DETECTION OF HUMAN HERPESVIRUS-8 ANTIGEN IN HIV-INFECTED PATIENTS IN EAST JAVA, INDONESIA. African Journal of Infectious Diseases (AJID), 12(2), 43-46. https://doi.org/10.21010/Ajid.v12i2.7
Background: Co-infection of human herpesvirus-8 (HHV-8) in HIV-positive people might cause Kaposi's sarcoma. Early
detection of HHV-8 may prevent the onset of clinical manifestations. In Indonesia, detection of HHV-8 antigen in HIVpositive
patients has yet to be reported. The intention of this research was to examine the presence of HHV-8 antigen in
HIV-positive patients in East Java, Indonesia.
Material and Methods: 103 serum samples were collected from HIV-positive patients in Surabaya and Tulungagung, East
Java, Indonesia. Serums were then tested for the presence of HHV-8 antigen by using sandwich ELISA.
Results: Human Herpesvirus-8 antigen was detected in 15 samples (14.5%). The presence of HHV-8 infection in HIVpositive
patients did not present differently in males and females and among different age groups. Human
immunodeficiency virus-positive serum samples were collected from 23 homosexual men, 25 intravenous drug users
(IVDUs) and 52 heterosexuals. In the male homosexual group, HHV-8 antigen was detected in 21.7% (5/23) of the
samples, while in the intravenous drug user group (IVDUs), 16% (4/25) of the samples were found to have HHV-8 antigen.
Conclusion: This research found the presence of HHV-8 antigen in 14.5% of patients in East Java, Indonesia. It is
recommended that patients with a positive result should receive further examination to detect any clinical manifestations
related to HHV-8 infection, especially in the form of Kaposi’s sarcoma lesions, so that the illness can be appropriately