EVALUATION OF IgG ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV), AND ASSOCIATED RISK FACTORS FOR SEVERE RESPIRATORY TRACT INFECTIONS IN PRE- SCHOOL CHILDREN IN NORTH-CENTRAL, NIGERIA.

Authors

  • Adedayo Faneye Department of Virology University of Ibadan
  • Babatunde O Motayo
  • Adeyinka Adesanmi
  • Bernard Onoja

Keywords:

RSV, Respiratory tract infection, Seroprevailence, Ilorin

Abstract

Background: Childhood mortality and morbidity due to RSV is increasing. Our current study was aimed at determining the sero-prevalence rate of RSV IgG antibodies and investigates certain known risk factors for RSV disease severity in infants and pre-school children presenting with various forms of respiratory tract infections in Ilorin, Nigeria. Materials and Methods: About 280, children and 30, aged matched controls were enrolled into the study at the specialist hospital Ilorin. Blood testing for anti RSV IgG was done using a commercial ELISA kit by IVD Research Inc® Carlsbad. California U.S.A. Information regarding Nutritional status, socio-economic status and other demographic variables were collected. Results: A prevalence rate of 85.7% was recorded among tested children and 23.3%, in controls, across age groups and gender. A statistically significant difference in age groups were recorded among patients with LRTI, (p <0.05), age <1 41%, age 1 <5, 27.6%. This was also the case for children with SRTI (Pneumonia and Bronchiolitis), with age < 1yr, 9%, and 1 <5yr, 19.8%. Analysed risk factors for disease severity showed thatnutritional status of children were statistically significant for disease severity, p-value, 0.039 (Chi square test). Conclusions: We report a high level of exposure to RSV in infancy and early childhood among children from a representative population in a major central Nigerian City, further studies into neutralising antibody levels and subtype distribution of RSV are advocated.

Author Biographies

Adedayo Faneye, Department of Virology University of Ibadan

Graduate student/researcher. Department of Virology University of Ibadan, Nigeria.

Babatunde O Motayo

Department of Virology University of Ibadan, Nigeria.

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Published

2014-05-01

How to Cite

Faneye, A., Motayo, B. O., Adesanmi, A., & Onoja, B. (2014). EVALUATION OF IgG ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV), AND ASSOCIATED RISK FACTORS FOR SEVERE RESPIRATORY TRACT INFECTIONS IN PRE- SCHOOL CHILDREN IN NORTH-CENTRAL, NIGERIA. African Journal of Infectious Diseases (AJID), 8(2), 36–39. Retrieved from https://journals.athmsi.org/index.php/AJID/article/view/2135

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