EVALUATION OF ORAQUICK® HIV-1/2 AS ORAL RAPID TEST

Authors

  • Celine Nguefeu Nkenfou "Chantal Biya" International Referenece Centre for Research on HIV/AIDS Prevention and Management (CIRCB) University of Yaounde I
  • Japhette Esther Kembou Faculty of Science,University of Dschang
  • Edith Saounde Temgoua "Chantal Biya" International Reference Centre for Research on HIV/AIDS Prevention and Management (CBIRC)
  • Appolinaire Djikeng Bioscience eastern and central Africa - International Livestock Research Institute Hub (BecA-ILRI Hub), Nairobi, Kenya
  • Linda Mekue Mouafo Faculty of Science, University of Dschang, Cameroon
  • Elvis Ndukong Ndzie Faculty of Science, University of Dschang, Cameroon
  • Irenee Donkam "Chantal Biya" International Reference Centre for Research on HIV/AIDS Prevention and Management (CBIRC)
  • Vitorrio Colizzi University of Rome Tor Vergata
  • Martin Sanou Sobze Faculty of Science, University of Dschang, Cameroon

Keywords:

OraQuick, OMT-based test, Diagnostic kits, National algorithm

Abstract

As Cameroon scales up its national HIV/AIDS control program, evaluating the performance of commercially available tests for accurate and cost effective diagnostics becomes essential. A cross-sectional study assessed the performance of an HIV oral rapid test. A total of 1520 participants consented to participate in the study. After counselling, they were tested for HIV using the national algorithm followed by OraQuick. Results of the national algorithm were compared to those of OraQuick, for sensitivity, specificity, positive predictive and negative predictive values. 62% of participants were male, and 1% was reported HIV-positive following the national algorithm. The OraQuick test had 93% sensitivity, 99% specificity, 99.93% NPV and 90% PPV (95% CI, Kappa 0.965). Though more expensive (2-6x) compared to the national algorithm tests, oral mucosal transudate-based test demonstrated good performance. Therefore, it could be implemented in resource-constrained settings if subsidized and could increase participation since less invasive with no blood accident exposure.

Author Biographies

Japhette Esther Kembou, Faculty of Science,University of Dschang

Departement of Animal Biology, M.Sc

Edith Saounde Temgoua, "Chantal Biya" International Reference Centre for Research on HIV/AIDS Prevention and Management (CBIRC)

Medical section, clinician researcher

Appolinaire Djikeng, Bioscience eastern and central Africa - International Livestock Research Institute Hub (BecA-ILRI Hub), Nairobi, Kenya

BecA-ILRI Hub, Technology Manager

Linda Mekue Mouafo, Faculty of Science, University of Dschang, Cameroon

Departement of Biochemistry, M.Sc

Elvis Ndukong Ndzie, Faculty of Science, University of Dschang, Cameroon

Departement of Biochemistry, M.Sc

Irenee Donkam, "Chantal Biya" International Reference Centre for Research on HIV/AIDS Prevention and Management (CBIRC)

Statistician, CBIRC

Vitorrio Colizzi, University of Rome Tor Vergata

Professor of Immunology, Director UNESCO Chair of Biotechnology

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Published

2013-08-05

How to Cite

Nkenfou, C. N., Kembou, J. E., Temgoua, E. S., Djikeng, A., Mouafo, L. M., Ndzie, E. N., Donkam, I., Colizzi, V., & Sobze, M. S. (2013). EVALUATION OF ORAQUICK® HIV-1/2 AS ORAL RAPID TEST. African Journal of Infectious Diseases (AJID), 7(2), 27–30. Retrieved from https://journals.athmsi.org/index.php/AJID/article/view/1685

Issue

Vol. 7 No. 2 (2013)

Section

Articles

License

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